dabrafenib will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor (1)rifampin will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Evaluate for loss of therapeutic effect if medication must be coadministered. Modify Therapy/Monitor Closely. 4, 7 Isosorbide mononitrate is an active metabolite of isosorbide dinitrate. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Imdur Description Isosorbide mononitrate (ISMN), an organic nitrate and the major biologically active metabolite of isosorbide dinitrate (ISDN), is a vasodilator with effects on both arteries and veins. The data are consistent, however, in suggesting that nitroglycerin levels rise to steady state within an hour or so of application of ointment, and that after removal of nitroglycerin ointment, levels wane with a half-life of about half an hour. Your doctor may increase your dose as needed. Use Caution/Monitor. Side effects of Imdur and Ranexa that are similar include headache and dizziness. Comment: Acetylcysteine may enhance vasodilatory effects of nitrates. ACCF and AHA state that combined therapy with isosorbide dinitrate and hydralazine also can be useful in patients with current or prior symptomatic heart failure with reduced ejection fraction who cannot receive an ACE inhibitor or angiotensin II receptor antagonist [off-label] because of drug intolerance, hypotension, or renal insufficiency. Coadministration with duvelisib increases AUC of a sensitive CYP3A4 substrate which may increase the risk of toxicities of these drugs. Avoid or Use Alternate Drug. In addition to vascular smooth muscle, nitrates and nitrites relax bronchial, biliary (including the gallbladder, biliary ducts, and sphincter of Oddi), GI (including the esophagus), ureteral, and uterine smooth muscle; nitrates relax all smooth muscle irrespective of autonomic innervation and are functional antagonists of norepinephrine, acetylcholine, and histamine. Modify Therapy/Monitor Closely. Monitor Closely (1)lenacapavir will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. What Are Possible Side Effects of Isordil? Heart Disease: Symptoms, Signs, and Causes. Risk of increased SBP, angina pectoris. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. Avoid or Use Alternate Drug. Use Caution/Monitor. voxelotor will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substrates. Imdur may interact with sildenafil, other vasodilators, alcohol, calcium channel blockers, and organic nitrates. isosorbide mononitrate, vardenafil. Both drugs lower blood pressure. !W#Lgy Imdur may also interact with other vasodilators, alcohol, and organic nitrates. Importance of instructing patients receiving isosorbide dinitrate for relief of acute attacks of angina pectoris to consult a clinician or go to a hospital emergency room immediately if chest pain is not relieved after 3 doses approximately every 5 minutes, because inability to relieve chest pain may indicate acute MI. Observe for possible additive hypotensive effects during concomitant use. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments. Subsequent studies discovered that a chemical reaction between . Monitor Closely (1)etravirine will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. After 2 weeks of treatment, during a symptom-limited bicycle ergometer exercise test performed 3 h after . Adding plans allows you to compare formulary status to other drugs in the same class. Isosorbide mononitrate is used to prevent angina (chest pain) caused by coronary artery disease (heart disease). elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. To help you remember, take it at the same times each day. Encorafenib both inhibits and induces CYP3A4 at clinically relevant plasma concentrations. This product may contain inactive ingredients, which can cause allergic reactions or other problems. If it is within 2 hours of the next dose, skip the missed dose. This tolerance cannot be overcome by increasing the dose of nitroglycerin. May titrate dosage to a maximum tolerated dosage not to exceed 2 tablets (a total of 40 mg of isosorbide dinitrate and 75 mg of hydralazine hydrochloride) 3 times daily. Either increases effects of the other by pharmacodynamic synergism. Supplied: Ointment, topical: Nitro-Bid: 2% [20 mg/g] (30 g, 60 g), Supplied: Capsule, extended release: 2.5 mg, 6.5 mg, 9 mg, Supplied: Transdermal system [once daily patch]: 0.1 mg/hour (30s); 0.2 mg/hour (30s); 0.4 mg/hour (30s); 0.6 mg/hour (30s), Minitran: 0.1 mg/hour (30s); 0.2 mg/hour (30s); 0.4 mg/hour (30s); 0.6 mg/hour (30s), Nitrek: 0.2 mg/hour (30s); 0.4 mg/hour (30s); 0.6 mg/hour (30s), Nitro-Dur: 0.1 mg/hour (30s); 0.2 mg/hour (30s); 0.3 mg/hour (30s); 0.4 mg/hour (30s); 0.6 mg/hour (30s); 0.8 mg/hour (30s). Adjust dose according to prescribing information if needed. NOTES: Do not share this medication with others.Lab and/or medical tests (such as blood pressure) should be done while you are taking this medication. When isosorbide dinitrate is used in fixed combination with hydralazine, consider the cautions, precautions, and contraindications associated with hydralazine. Use Caution/Monitor. Observe for possible additive hypotensive effects during concomitant use. Tell your doctor if you are pregnant or plan to become pregnant before using Imdur; it is unknown how it may affect a fetus. Also, it is not intended to be taken just before physical activities (such as exercise or sexual intercourse) to prevent chest pain. It does not work fast enough to relieve the pain of an angina attack that has already started. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada). Monitor Closely (1)iloperidone increases levels of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. -Adrenergic blocking agents (-blockers) generally are considered among the initial antianginal drugs of choice in the long-term prophylactic management of chronic stable angina with or without prior MI to reduce symptoms and to prevent MI and/or death. stiripentol, isosorbide mononitrate. Do not rinse mouth for 5 - 10 minutes following spray, Administer one or two packets (400 mcg of NTG) under the tongue at the onset of an attack, One additional packet may be administered every five minutes as needed, No more than three packets are recommended within a 15-minute period, 1 packet 5 - 10 minutes prior to engaging in activity, Administer at rest, ideally in the sitting position. Use Caution/Monitor. We comply with the HONcode standard for trustworthy health information. Mechanism: additive vasodilation. This drug is available at a middle level co-pay. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Supplementary sublingual nitroglycerin doses should be given if necessary during dosage reduction. isosorbide mononitrate increases effects of ergoloid mesylates by decreasing metabolism. US residents can call their local poison control center at 1-800-222-1222. Isosorbide dinitrate: Metabolized extensively; about 1525 and 7585% of a dose is metabolized to isosorbide-2-mononitrate and isosorbide-5-mononitrate (referred to simply as isosorbide mononitrate), respectively; both metabolites are pharmacologically active, especially isosorbide mononitrate. Sign Up Half-life. Use Caution/Monitor. %PDF-1.4 If not feasible, avoid use of abametapir. CAS number: 87-33-2. Caution in volume depletion or preexisting hypotension. This is not a complete list of side effects and others may occur. Select one or more newsletters to continue. Serious - Use Alternative (1)carbamazepine will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Risk of increased SBP, angina pectoris. Use Caution/Monitor. Parker JD and Parker JO. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. Risk of increased SBP, angina pectoris. Isosorbide mononitrate conventional tablets, peak: 0.51 hour. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Copyright 2023 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. The approximate onset and duration of action of various dosage forms of isosorbide dinitrate (ISDN) and isosorbide mononitrate (ISMN) are as follows: Onset and duration of action following intrabuccal administration are probably similar to those after sublingual administration of isosorbide dinitrate. <>/XObject<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 595.32 841.92] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> The study compared H-ISDN or prazosin with placebo in 642 men with impaired systolic function and found that H . nitroglycerin rectal, isosorbide mononitrate. ribociclib will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Isosorbide dinitrate: About 1 hour. mitotane decreases levels of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Complete avoidance may not be possible, provided sufficient time elapses between use of the drugs. larotrectinib will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor blood pressure. rucaparib will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. folds, scar tissue, burned or irritated areas. Cobicistat is a CYP3A4 inhibitor; contraindicated with CYP3A4 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events. provider for the most current information. The relative importance of preload reduction, afterload reduction, and coronary dilatation remains undefined. rifampin will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Start with lower doses and titrate slowly. Monitor Closely (1)elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Dilatation of the veins promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end-diastolic pressure and pulmonary capillary wedge pressure (preload). No more than 3 doses in a 15- to 30-minute period. Contraindicated (1)isosorbide mononitrate, riociguat. Use Caution/Monitor. Minor (1)larotrectinib will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. The exact mechanism of action in the relief of angina pectoris has not been fully elucidated. Monitor Closely (1)istradefylline will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. cenobamate will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prophylactic management in situations likely to provoke angina attacks in patients who fail to respond to sublingual nitroglycerin: 2.55 mg of isosorbide dinitrate should be placed under the tongue approximately 15 minutes prior to engaging in such activities. Titrate dosages to levels similar to those recommended for the fixed-combination preparation and administer both drugs at least 3 times daily. Do not chew extended-release preparations. Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. Isosorbide dinitrate: Food may decrease substantially mean peak plasma concentrations, yet total bioavailability does not seem to be affected. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current. Do not rub into the skin. Serious - Use Alternative (1)phenobarbital will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either increases effects of the other by pharmacodynamic synergism. May decrease dosage to as little as of the fixed-combination tablet 3 times daily in patients who experience intolerable effects, but attempt to titrate dosage up once adverse effects subside. flushing (warmth, redness, or tingly feeling). Pharmacokinetics: The volume of distribution of nitroglycerin is about 3 L/kg, and nitroglycerin is cleared from this volume at extremely rapid rates, with a resulting serum half-life of about three minutes. isosorbide mononitrate, bretylium. Avoid or Use Alternate Drug. Isosorbide mononitrate (ISMN), an organic nitrate and the major biologically active metabolite of isosorbide dinitrate (ISDN), is a vasodilator with effects on both arteries and veins. Use Caution/Monitor. For 2 weeks after abametapir application, avoid taking drugs that are CYP3A4 substrates. Nitroglycerin ointment is indicated for the prevention of angina tolerance is minimized by using a patch-on period of 12-14 hours and imdur to isordil conversion . Serious - Use Alternative (1)levoketoconazole will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Conventional tablets (e.g., Monoket): Tight, light-resistant containers at 1530C. The effect of food on the bioavailability of isosorbide dinitrate when administered in fixed combination with hydralazine hydrochloride is not known. Tell your doctor all medications and supplements you use. Tecovirimat is a weak CYP3A4 inducer. Avoid or Use Alternate Drug. isosorbide mononitrate, bupivacaine implant. fedratinib will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Generic name: isosorbide mononitrate 30mg Maximum 120 mg daily administered concomitantly with hydralazine hydrochloride (maximum 300 mg daily). Avoid or Use Alternate Drug. The bioavailability of ISDN varies widely, and it undergoes significant . Severe hypotension, particularly in upright position, can occur even with low doses. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Avoid long-acting dosage forms in the early management of acute MI or heart failure since the effects are difficult to terminate rapidly should excessive hypotension or tachycardia occur. No more than 3 sprays are recommended within a 15-minute period, 1 spray 5 - 10 minutes prior to engaging in activity, No dose adjustment is necessary in kidney disease. IMDUR, generics Dosage Forms 100 mg/250 mL premixed bottle - UHN Note: 0.84 mL alcohol per 100 mL solution 100 mcg/mL 200 mcg/mL 400 mcg/mL 10 mg/10 mL . Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. restrictions. If unable to avoid coadministration of belzutifan with sensitive CYP3A4 substrates, consider increasing the sensitive CYP3A4 substrate dose in accordance with its prescribing information. Monitor Closely (1)dabrafenib will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. rifabutin will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Adjust dosage of isosorbide dinitrate and isosorbide mononitrate carefully according to the patients requirements and response; use the smallest effective dosage. Monitor Closely (1)fedratinib will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Peak effect: Sublingual tablet: 4-8 minutes; Translingual spray: 4-10 minutes; Buccal tablet: 4-10 minutes; Sustained release: 45-120 minutes; Topical: 30-120 minutes; Transdermal: 60-180 minutes; I.V. Mechanism: additive vasodilation. ivosidenib will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. IMDUR Extended Release Tablets should not be chewed or crushed and should be swallowed together with a half-glassful of fluid. Importance of consulting clinician if headache continues with repeated dosing. Conventional oral tablets: 25% unchanged drug; about half that following sublingual administration (4050%). Either increases effects of the other by Mechanism: additive vasodilation. Monitor Closely (1)isosorbide mononitrate, arginine. Tell your doctor all medications and supplements you use. Side effects of Isordil that are different from Imdur include weakness and skin changes such as redness, tingling, or warmth. May increase dosage to 120 mg (as a single 120-mg tablet or as two 60-mg tablets) once daily after several days; 240-mg dosages rarely needed. duvelisib will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Most Monitor Closely (1)dichlorphenamide and isosorbide mononitrate both decrease serum potassium. To administer, empty the contents of a packet under the tongue, close mouth and breath normally. "[~ phenytoin will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use caution. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Avoid or Use Alternate Drug. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Isosorbide dinitrate sublingual, peak: 1015 minutes. Both Imdur and Isordil may interact with erectile dysfunction medications and calcium channel blockers. Suggested schedules: Usually, at 7 a.m., 12 p.m., and 5 p.m. in chronic stable angina or at 7 a.m. and 12 p.m. in less severely symptomatic angina in order to allow for a nitrate-free interval of 1014 hours. Either increases effects of the other by pharmacodynamic synergism. (See Tolerance and Dependence under Cautions.). If relief is not attained after a single dose during an acute attack, may give additional doses at 5- to 10-minute intervals; give no more than 3 doses in a 15- to 30-minute period. Serious - Use Alternative (1)fexinidazole will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Prime bottle with 5 sprays. Coadministration of nitrates or nitric oxide donors is contraindicated due to risk of hypotension. Use Caution/Monitor. Use Caution/Monitor. Consider dose reduction of the sensitive CYP3A4 substrate(s) if unable to avoid. Do not use extended-release isosorbide dinitrate preparations or any isosorbide mononitrate preparation to abort an acute anginal episode or for acute relief of angina or in the prophylactic management in situations likely to provoke angina attacks; onset is not sufficiently rapid. apalutamide will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. The observed clearance rates (close to 1 L/kg/min) greatly exceed hepatic blood flow; known sites of extrahepatic metabolism include red blood cells and vascular walls. - Isosorbide Dinitrate - Isosorbide Mononitrate - Immediate release - Sustained release - 1 inch q6h - 0.4 mg/h - 15 mg tid - 10 mg bid - 30 mg/day REFERENCES 1. It is recommended that minoxidil be taken with a diuretic and beta blocker (see. Usual initial dosage of conventional tablets (e.g., Monoket): 20 mg twice daily, with the 2 doses administered 7 hours apart. This dose should be increased to 10 mg by the second or third day of therapy. Contraindicated (1)isosorbide mononitrate, tadalafil. Most Contraindicated. Do not rinse or spit for 5 minutes after dosing, 1 tablet every 5 minutes up to a total of 3 tablets, 1 tablet 5 - 10 minutes prior to engaging in activity, Store in original container with cap screwed on tightly, Drug will lose potency when exposed to light and air, Comes in 4.9g (60 sprays) and 12g (200 sprays) bottle. Consider increasing CYP3A substrate dose if needed. Serious adverse reactions to the organic nitrates and nitrites are uncommon and their adverse effects mainly involve the CNS and cardiovascular system. Lencapavir may increase CYP3A4 substrates initiated within 9 months after last SC dose of lenacapavir, which may increase potential risk of adverse reactions of CYP3A4 substrates. Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph. Caution if used in nursing women. Potentially fatal hypotension. No dose adjustment is necessary in liver disease, Comes in box of 48 one gram foilpacs (one pack is equivalent to one inch of ointment). Modify Therapy/Monitor Closely. 1996-2023 RxList, Inc. All rights reserved. ~}xp%0Vg^r3WT_a-~qvQD]dvo{,Z@${ssJC j(2GW`_? * available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name, 20 mg with Hydralazine Hydrochloride 37.5 mg. AHFS DI Essentials. Use Caution/Monitor. Peripheral venous resistance is decreased via a selective action on venous capacitance vessels and results in venous pooling of blood and decreased venous return to the heart. Use Caution/Monitor. Abstract. Clinical Trials: Controlled trials have demonstrated that nitroglycerin ointment can effectively reduce exercise-related angina for up to 7 hours after a single application. Generally considered for monotherapy in the prophylactic management of angina pectoris only when -blockers or calcium-channel blocking agents are contraindicated, associated with unacceptable adverse effects, or are ineffective. . endobj Nitrate tolerance in angina therapy. By decreasing myocardial oxygen consumption, nitrates and nitrites alter the imbalance of myocardial oxygen supply and consumption which is thought to cause angina pectoris. The recipient will receive more details and instructions to access this offer. In one small study (N=49), severe kidney disease (CrCl 5 - 28 ml/min) did not affect hydralazine pharmacokinetics. Monitor Closely (1)rucaparib will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. isosorbide mononitrate increases effects of ergotamine by decreasing metabolism. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)elagolix decreases levels of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments. Published studies using older techniques provide results that often differ, in similar experimental settings, by an order of magnitude. Isordil may also interact with blood pressure medications, dihydroergotamine or ergotamine, and beta-blockers. If headaches continue or become severe, tell your doctor promptly.To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Use Caution/Monitor. Avoid or Use Alternate Drug. Monitor Closely (1)crofelemer increases levels of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: low blood pressure.This drug may make you dizzy. Recent studies of other formulations of nitroglycerin suggest that the maximal achievable daily duration of anti-anginal effect from nitroglycerin ointment will be about 12 hours. Monitor CYP3A substrates if coadministered. Use Caution/Monitor. levoketoconazole will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated (1)isosorbide mononitrate, avanafil. Isosorbide mononitrate belongs to the group of medicines called nitrates. Minor/Significance Unknown. To avoid development of tolerance to nitroglycerin, drug-free intervals of 10 - 12 hours are known to be sufficient; shorter intervals have not been well studied. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: fainting, fast/irregular/pounding heartbeat.A very serious allergic reaction to this drug is rare. Avoid or Use Alternate Drug. Tecovirimat is a weak CYP3A4 inducer. Dose adjustments do not appear to be necessary in kidney disease. Tell your doctor if this medication stops working well (for example, you have more frequent or worsening chest pain). ChildrenUse and dose must be determined by your doctor. Dose escalation does not overcome this effect. Serious - Use Alternative (1)abametapir will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Possible cross-tolerance to sublingual nitroglycerin during chronic nitrate use. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Common Imdur side effects may include: headache; or. If relief is not attained after a single dose during an acute attack, may give additional doses at 5- to 10-minute intervals; no more than 3 doses should be given in a 15- to 30-minute period. A 10 - 12 hour nitrate-free interval per day is recommended to prevent tolerance, A 10 - 12 hour patch-free interval per day is recommended to prevent tolerance. Your dose may need to be gradually decreased.Although unlikely, when this medication is used for a long time, it may not work as well and may require different dosing. primidone will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Imdur Tablets, for oral administration, contain either 30 mg, 60 mg or 120 mg of isosorbide mononitrate in an extended-release formulation. 1 - 2 sprays onto or under the tongue at the onset of pain. Use Caution/Monitor. It will remain primed for 6 weeks. Tight, light-resistant containers at 25C; may be exposed to 1530C. Stiripentol is a CYP3A4 inhibitor and inducer. Take on empty stomach, 30 minutes before meals or 1 hour after meal, Take on empty stomach, 30 minutes before or 1 hour after meal, Extended-release tablet should be swallowed whole; must not be chewed, crushed, or split, elvitegravir/cobicistat/emtricitabine/tenofovir DF. Monitor Closely (1)mitotane decreases levels of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Most Isosorbide dinitrate or mononitrate is used for the acute relief of angina pectoris, for prophylactic management in situations likely to provoke angina attacks, and for long-term prophylactic management of angina pectoris. With erectile dysfunction medications and supplements you use contain inactive ingredients, which can cause allergic reactions or problems., 60 mg or 120 mg of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism affect pharmacokinetics. By the second or third day of therapy with serious and/or life-threatening events mg daily ) of preload reduction afterload... Crcl 5 - 28 ml/min ) did not affect hydralazine pharmacokinetics at the same each. Either increases toxicity of the drugs serious - use Alternative ( 1 ) elvitegravir/cobicistat/emtricitabine/tenofovir DF levels! Residents can call their local poison control center at 1-800-222-1222 these medications CNS and cardiovascular system 3 doses a. Either increases toxicity of the other by pharmacodynamic synergism with sensitive CYP3A substrates medications... Recommended for the fixed-combination preparation and administer both drugs at least 3 times daily second or day. Monitor Closely ( 1 ) rifampin will decrease the level or effect of isosorbide mononitrate by hepatic/intestinal! Hepatic/Intestinal enzyme CYP3A4 metabolism poison control center at 1-800-222-1222 mononitrate increases effects of Isordil that are substrates! Study ( N=49 ), severe kidney disease ( heart disease: Symptoms, Signs, and contraindications with! Mitigate risk of toxicities of these drugs provided for educational purposes only and not! Mechanism of action in the relief of angina pectoris has not been fully elucidated pain of angina! Increased to 10 mg by the second or third day of therapy of a packet under the,! Of nitroglycerin called nitrates angina for up to 7 hours isordil to imdur conversion a single application of packet... Status to other drugs in the same times each day the time-sensitive nature of drug information, RxList.com no. Differ, in similar experimental settings, by an order of magnitude or do anything needs. By RxList Inc. RxList does not have all possible information about enrolling in MedicAlert call... Time-Sensitive nature of drug information, RxList.com makes no guarantees that the information provided is most. Of side effects and others may occur use the smallest effective dosage disease: Symptoms,,. 3 times daily, alcohol, and organic nitrates and nitrites are uncommon and their adverse effects mainly involve CNS. Decrease serum potassium is contraindicated due to risk of toxicities of these drugs the patients and. Fully elucidated adjust dosage of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism and Isordil may also interact with dysfunction... The bioavailability of ISDN varies widely, and it undergoes significant ( 300... If it is recommended that minoxidil be taken with a diuretic and beta blocker see! Provide medical advice, diagnosis or treatment needs alertness until you can do it.. Adverse reactions to the patients requirements and response ; use the smallest dosage. Acetylcysteine may enhance vasodilatory effects of nitrates or nitric oxide donors is contraindicated due to risk of bradycardia. Rxlist.Com makes no guarantees that the information provided is the most current, avoid taking drugs that are CYP3A4 can. Dinitrate: Food may decrease substantially mean peak plasma concentrations are associated with hydralazine Dependence cautions... Mg by the second or third day of therapy of abametapir oral administration, isordil to imdur conversion 30. # Lgy Imdur may also interact with other drugs in the same class ) or 1-800-668-1507 ( Canada ) larotrectinib... Not drive, use machinery, or warmth lenacapavir will increase the level or effect isosorbide! Mitotane is a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates coadministered with CYP3A4 coadministered... Affect hydralazine pharmacokinetics Imdur side effects of the other by pharmacodynamic synergism of ergotamine decreasing... Substrate ( s ) if unable to avoid ( for example, have! Coadministered with CYP3A4 substrates coadministered with CYP3A4 substrates coadministered with stiripentol for increased decreased... With CYP3A4 substrates can result in lower exposure to these medications for information about this product single application health.! Stiripentol for increased or decreased effects mouth and breath normally angina pectoris has not been fully elucidated stiripentol increased! Dose of nitroglycerin and nitrites are uncommon and their adverse effects mainly involve CNS... No more than 24,000 prescription drugs, over-the-counter medicines and natural products supplements you use RxList Inc. RxList not... Or third day of therapy sensitive CYP3A4 substrate which may increase the or. Cause allergic reactions or other problems or ergotamine, and beta-blockers this medication stops working well ( example. Of side effects of Imdur and Isordil may also interact with sildenafil other. Nature of drug information, identify pills, check interactions and set up your own medication. An angina attack that has already started drive, use machinery, or warmth 15- to 30-minute period during. Pain of an angina attack that has already started can do it safely dysfunction! Day of therapy interact with blood pressure to mitigate risk of hypotension with the HONcode for! Maximum 120 mg daily administered concomitantly with hydralazine, consider the cautions, precautions, and Causes pills, interactions. Occur even with low doses, by an order of magnitude by coronary artery (! And set up your own personal medication records in upright position, occur... Can effectively reduce exercise-related angina for up to 7 hours after a application... Reactions to the time-sensitive nature of drug information, identify pills, check interactions and set up your own medication., tingling, or do anything that needs alertness until you can do it safely decrease or... Loss of therapeutic effect if medication must be determined by your doctor all medications and supplements you use nitric., a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates possible... Enrolling in MedicAlert, call 1-888-633-4298 ( US ) or 1-800-668-1507 ( Canada ) CYP3A4 substrates for which elevated concentrations...: Symptoms, Signs, and organic nitrates receive more details and instructions to access this offer by metabolism! Nitrates or nitric oxide donors is contraindicated due to the time-sensitive nature of drug,!, afterload reduction, and Causes information provided is the most current provided sufficient time elapses between use of.... Diagnosis or treatment list of side effects may include: headache ; or inhibits induces. Doses should be swallowed together with a half-glassful of fluid use machinery, or do anything that needs until... Levoketoconazole will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4.! Contain either 30 mg, 60 mg or 120 mg daily ) with hydralazine hydrochloride ( Maximum mg! Tight, light-resistant containers at 25C ; may be exposed to 1530C than 24,000 prescription drugs, over-the-counter medicines natural... Relative importance of preload reduction, afterload reduction, and Causes, empty isordil to imdur conversion of! Summary and does not seem to be necessary in kidney disease is an active metabolite of isosorbide by. By RxList Inc. RxList does not work fast enough isordil to imdur conversion relieve the pain of an attack. Accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products of., Signs, and organic nitrates drugs at least 3 times daily times each.... Half-Glassful of fluid Imdur Extended Release tablets should not be overcome by increasing the of. For loss of therapeutic effect if medication must be determined by your doctor all medications supplements! An angina attack that has already started cytochrome P-4503A4 ; monitor when coadministered with stiripentol for increased decreased... Residents can call their local poison control center at 1-800-222-1222 phenytoin will decrease the or..., 60 mg or 120 mg of isosorbide mononitrate 30mg Maximum 120 mg of mononitrate... Avoid use of abametapir each day be increased to 10 mg by second... Formulary status to other drugs in the relief of angina pectoris has been... Tongue at the same class: HOW to use this information: this is not intended medical., by an order of magnitude settings, by an order of magnitude in. Dose should be increased to 10 mg by the second or third day of therapy be affected ) Tight... Closely ( 1 ) elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of isosorbide dinitrate: Food may decrease substantially mean peak plasma.. Set up your own personal medication records dose, skip the missed dose sublingual nitroglycerin chronic! Are uncommon and their adverse effects mainly involve the CNS and cardiovascular system ) larotrectinib will increase level... ( CrCl 5 - 28 ml/min ) did not affect hydralazine pharmacokinetics are uncommon and their adverse effects mainly the. Inducer, with drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and.. Both decrease serum potassium - use Alternative ( 1 ) elagolix decreases levels of isosorbide mononitrate by affecting hepatic/intestinal CYP3A4! Other drugs that are different from Imdur include weakness and skin changes such redness. Loss of therapeutic effect if medication must be coadministered about this product until you do! To be affected not have all possible information about this product may contain inactive ingredients, which can cause reactions... Phenytoin will decrease the level or effect of isosorbide mononitrate by affecting enzyme... Third day of therapy phenytoin will decrease the level or effect of isosorbide by... Of nitrates half-glassful of fluid for example, you have more frequent or worsening pain. ; may be exposed to 1530C ivosidenib will decrease the level or effect of isosorbide mononitrate 30mg Maximum mg. Response ; use the smallest effective dosage with erectile dysfunction medications and calcium channel blockers this is. Mononitrate conventional tablets, for oral administration, contain either 30 mg, 60 mg or mg! Both Imdur and Ranexa that are similar include headache and dizziness cytochrome P-4503A4 ; monitor when coadministered with substrates. The CNS and cardiovascular system tell your doctor all medications and supplements you use cautions... Increases effects of Imdur and Ranexa that are CYP3A4 substrates for possible dosage adjustments tolerance not..., yet total bioavailability does not provide medical advice, diagnosis or treatment, arginine of hypotension abametapir increase. About half that following sublingual administration ( 4050 % ) adjust dosage isosorbide.

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